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HUS is a. Micro-angiopathic haemolytic anaemia (indicated by fragmented red cells on blood film OR plasma lactate
dehydrogenase (LDH) above local centre reference range)
AND b. Thrombocytopenia (platelets <150x109/l)
AND c. Acute Kidney Injury (AKI): “injury” or “failure” category of pRIFLE criteria despite correction of hypovolaemia
Why? To assess whether Eculizumab (Ecu) reduces the severity of Shiga-toxin producing Escherichia coli Haemolytic Uraemic syndrome (STEC HUS) in children and young people.
To find out more: contact Renal Doctors Dr Angela Hall or Dr Sudarsana De
or take a look at the ECUSTEC website
Why? This will give a much better understanding of how these illnesses affect people. It will also speed up research.
To find out more: contact Dr Angela Hall or Research Nurse Jackie Philps
or go to the RaDaR website
Why? Your child’s kidney specialist has made a diagnosis of Nephrotic Syndrome (NS). This can be described as either:
SSNS is usually a milder disease and most cases respond to steroids, but occasionally it becomes resistant to steroids and is then termed SRNS. The cause of this is rarely known and SRNS/FSGS can be very difficult to treat. The treatment itself can have side effects and appears to be more effective in some than in others.
For this reason we want to find out:
To find out more: contact your Renal Doctor Dr Angela Hall or Dr Sudarsana De, or Research Nurse Jackie Philps
Or take a look at the NEPHROS website
There may be other renal studies, which we haven’t listed here.
Please ask your Doctor about research that may be suitable for you or your child.
It’s OK to Ask.